Potent Medicine is one of the many items you must collect in Persona 3 Reload. This item is special because you need it to complete one of Elizabeth’s requests.
At the start of 6/13, Request 20 becomes unlocked, which tasks you to bring her a specific Medicine you can’t find anywhere else. You won’t find this particular item in the Pharmacy or any stores.
I should know. I spent over an hour going between stores in Paulownia Mall, Iwatodai Strip Mall, and Port Island Station and even talking to a ton of NPCs to see if I could get a flag to appear and find out where it was. But I had no luck at all.
That’s because this item, Potent Medicine, can only be found in one particular location. After getting it, there is no other way to acquire it.
Persona 3 Reload Request 20: Bring me some potent medicine
Potent Medicine is found in the Nurse’s Office on the first floor of Gekkoukan High School in Persona 3 Reload. Head down the West corridor, past the Faculty office.
The item will only spawn after accepting Request 20 from Elizabeth. A line of text pops up before you enter to meet the nurse, who gives you the Potent Medicine after a lengthy piece of dialogue. If you try entering the Nurse’s Office before or after the request has been accepted, you will waste the day listening to a lecture that increases your stats.
This is one of a long line of Elizabeth requests that’ll have you randomly checking every door in Gekkoukan High School for specific items. So be prepared to come back here a lot to finish a slew of requests about to be unlocked one after another. But it will be worth it on your mission to complete them all.
When returning to Elizabeth with the Potent Medicine, you are rewarded a Steel Pipe weapon. This is a useful weapon to use in the early game, but if you finish the request later on, like I did, it’ll leave a sour taste in your mouth.
